Lauréats de l’appel à projets "Grants scientifiques 2024"
Dans le cadre de son 100e anniversaire et grâce à la générosité de ses donateurs, la Fondation contre le Cancer a octroyé un montant exceptionnel de près de 35 millions d’euros pour le financement de 68 projets de recherche en oncologie.
Ces projets innovants visent à mieux comprendre la maladie, à augmenter les taux de guérison et à améliorer la qualité de vie des personnes atteintes d’un cancer.
Les lauréats sélectionnés par des conseils scientifiques indépendants sont les suivants :
Recherche fondamentale : 42 projets & 21 015 359 €
Equipe(s) de recherche
Institution(s)
Montant
Type de cancer
Type de traitement
Titre du projet
Aerts Stein
KU Leuven
600.000 €
Cerveau
Modeling and synthetic design of transcriptional enhancers to target cell states in glioblastoma and its microenvironment
Alsteens David
UCLouvain
336.000 €
Sein
Immunothérapie
The Role of Sialylation in Cancer-Macrophage Interactions: Impact CD169 Context-Dependent Signalling
Amant Frédéric
KU Leuven
479.939 €
Chimiothérapie
Treating pregnant cancer patients with chemotherapy causes a persistent mutagenic imprint in the offsprings blood? (IMPRINT)
Bergers Gabriele
KU Leuven
480.000 €
Immunothérapie
Hemorrhage-induced HO-1 macrophages infer resistance to antiangiogenic immunotherapies in cancer
Berx Geert
Universiteit Gent
477.309 €
Colorectal
Immunothérapie
Plasticity controlled colon cancer initiation and progression
Blanpain Cédric
Université Libre de Bruxelles
600.000 €
Peau
Mechanisms leading to the elimination of looser cells by cell competition during tumor initiation
Blomme Arnaud
Université de Liège
480.000 €
Poumon
Lipotranslate - Targeting lipid-induced mRNA translation reprogramming as a strategy to improve therapy in lung cancer
Chariot Alain
Université de Liège
480.000 €
Foie
Translational reprogramming through tRNA modifications in cancer
Close Pierre
Université de Liège
480.000 €
Immunothérapie
tRNA epitranscriptomics: a new vulnerability in cancer
De Keersmaecker Kim
KU Leuven
600.000 €
Leucémie
Traitement ciblé
Ribosomal protein mutations in cancer: diversity in oncogenic mechanisms
De Preter Katleen
Universiteit Gent
430.368 €
Neuroblastome
Tracking cfDNA origin during therapy in barcoded cancer models
De Wever Olivier
Universiteit Gent
480.000 €
Ovaire
Traitement ciblé
Impact of MEK targeted therapy on cancer-associated fibroblast state and consequential effects for cancer progression
Feron Olivier
UCLouvain
480.000 €
Chimiothérapie
Nexus between Tumor Acidosis and Drug Tolerant Persister Cells
Fuks François
Université Libre de Bruxelles
589.000 €
Sein
Role of the connection between epigenetics and epitranscriptomics in breast cancer
Guilliams Martin & Vermeulen Peter
Universiteit Gent & GZA Ziekenhuizen Sint Augustinus
600.000 €
Foie
MeTAMorphosis
Halder Georg
KU Leuven
600.000 €
Foie
Traitements combinés
Suppressing mechano-induced resistance to Ras/MAPK pathway inhibitors by combinatorial treatment with TEAD inhibitors
Hendrix An
Universiteit Gent
480.000 €
Sein
Immunothérapie
Targeting Rab27b-mediated release of extracellular vesicles to suppress cancer progression and elicit cGAS-mediated anti-cancer immunity
Hennequart Marc
UNamur
480.000 €
Pancréas
Traitement ciblé
Harnessing the metabolic switch that occurs in early pancreatic cancer events for therapy and detection
Herfs Michael
Université de Liège
464.000 €
Peau
Immunothérapie & Radiothérapie
Deciphering the hijacking of host DNA damage/repair mechanisms by Merkel cell polyomavirus and its associated critical vulnerabilities
Janssens Sophie
Universiteit Gent
480.000 €
Immunothérapie & Chimiothérapie
Immunogenic cell death from a dendritic cell perspective, some old concepts revisited
Lambrecht Bart
Universiteit Gent
475.696 €
Poumon
Immunothérapie
Type 2 inflammation in lung cancer
Lambrechts Diether
KU Leuven
660.000 €
Immunothérapie
Deciphering the tumor antigen landscape of CD4+ T-cells during checkpoint immunotherapy
Leucci Eleonora
KU Leuven
600.000 €
Peau
Immunothérapie
Characterisation of a novel immune checkpoint peptide
Lucas Sophie
Institut de Duve
600.000 €
Immunothérapie
Understanding the mechanisms underpinning the immunotherapeutic activity of GARP:TGF-β1 blockade in cancer
Mazzone Massimiliano
KU Leuven
720.000 €
Sein
Immunothérapie
Epigenetic regulation as a main instructor guiding tumor-associated macrophage phenotypes: can we revert the trend?
Menu Eline
Vrije Universiteit Brussel
428.000 €
Myélome multiple
Immunothérapie
Elucidating immune suppressive mechanisms against CAR T therapy
Ntziachristos Panagiotis
Universiteit Gent
600.000 €
Leucémie
RNA methylation controls oncogenic transcription and metabolism in T-cell leukemia
Rapino Francesca
Université de Liège
476.000 €
tRNA dynamics shapes intestinal cancer stem cell phenotypes.
Remsik Jan
KU Leuven
480.000 €
Cerveau
Immunothérapie
Untangling the interactome of dendritic cells in leptomeningeal metastasis
Scheele Colinda
KU Leuven
454.356 €
Sein
Deconstructing the dynamic interplay between mutant cells and their environment as a driver of mammary tumor initiation
Swinnen Johannes
KU Leuven
360.000 €
Pancréas
Immunothérapie
Immunolipidomics: targeting lipid antigens to combat pancreatic cancer
Taghon Tom
Universiteit Gent
478.233 €
Immunothérapie
Using spatial transcriptomics to identify the molecular drivers of human γδ subset development for tailored cancer immunotherapy
Tarabichi Maxime
Université Libre de Bruxelles
300.692 €
Thyroïde
The somatic evolution of the thyroid: retracing the path to cancer in vivo
Tejpar Sabine
KU Leuven
476.800 €
Colorectal
Immunothérapie
Understanding and combatting niches of inflammation and antigenicity as immune-surveillance strategies in colorectal cancer
Van den Eynde Benoit
Institut de Duve
480.000 €
Immunothérapie
The role of Integrated Stress Response in modulating immune cells in the tumor microenvironment
Vandesompele Jo
Universiteit Gent
480.000 €
Neuroblastome
Traitement ciblé
Study of acquired resistance and recurrence through multi-omics spatial analysis of neuroblastoma
van Gastel Nick
Institut de Duve
480.000 €
Leucémie
Targeting metabolic niche support to eliminate residual leukemic stem cells
Van Ginderachter Jo
Vrije Universiteit Brussel
469.056 €
Poumon
Lung cancer-induced alterations in the bone marrow progenitor and monocyte compartment with implications for tumor-associated and healthy tissue macrophages
Vereecke Lars
Universiteit Gent
580.000 €
Colorectal
Immunothérapie
Microbial drivers of colorectal cancer development and therapy
Voet Thierry & Piessevaux Hubert
KU Leuven & UCLouvain
479.910 €
Colorectal
Bridging biology to histology through spatially informed assays in early colorectal cancer: towards clinical pathology 2.0
Willems Luc
Université de Liège
360.000 €
Leucémie
The HTLV-1 retrovirus subverts the HLTF antiviral restriction factor to induce adult T-cell leukemia
Zhu Jingjing
Institut de Duve
480.000 €
Immunothérapie
α2-Adrenergic Receptor Agonists in Cancer Immunotherapy: Unraveling the Mechanisms of Action
Recherche translationnelle et clinique : 26 projets &
13 899 679 €
Equipe(s) de recherche
Institution(s)
Montant
Type de cancer
Type de traitement
Titre du projet
Albersen Maarten
UZ Leuven
547.500 €
Génito-urinaire
Immunothérapie & Chimiothérapie
Advancing Penile, Vulvar and Urethral Squamous Cell Carcinoma management by identifying tissue and blood-based signals for immunochemotherapy response
Amant Frédéric
KU Leuven
350.000 €
Col de l’utérus
Optimization of Staging and Treatment in Pregnant Patients with Cervical Cancer
Berghmans Thierry
Institut Jules Bordet
548.322 €
Poumon
Immunothérapie
Fibroblast activation protein targeted radioligand therapy as potential inverter of the immune escape mechanism of non-small cell lung cancers (FAP-Lu-ng)
Beuselinck Benoit
KU Leuven
400.000 €
Rein
Immunothérapie
Translational biomarker research in metastatic renal cell carcinoma treated with immune checkpoint inhibitors and/or angiogenesis inhibitors
Buisseret Laurence
Institut Jules Bordet
596.000 €
Sein
Immunothérapie & Radiothérapie
Immune priming of the tumor microenvironment in Luminal B Breast Cancer
Cataldo Didier
Université de Liège
300.000 €
Poumon
Immunothérapie
Effects of Air Pollution on the Recruitment of PolyMorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSCs) into the Lung Parenchyma and consequences of PMN-MDSCs on the efficacy of treatments by immune checkpoints inhibitors
De Keersmaecker Kim
KU Leuven
600.000 €
Lymphome
Traitements combinés
Sertraline combination therapy for T-cell malignancies: Mode of action and preclinical optimization
Demeulemeester Jonas
KU Leuven
485.000 €
Sarcome
AGENDAS – Advanced Genomics for Sarcoma Diagnosis and Care
Deroose Christophe
UZ Leuven
593.176 €
Myélome multiple
First-in-man and phase 2 study in multiple myeloma patients of [18F]F-AlF-NOTA-SC, a fluorine-18 labeled PET tracer for CXCR4.
Devoogdt Nick
Vrije Universiteit Brussel
596.000 €
Immunothérapie
CHOPIN: CD8 lympHOcyte PET Imaging with a Nanobody tracer
Fuks François
Université Libre de Bruxelles
582.000 €
Leucémie
Traitements combinés
Innovative combination of epigenetic drugs: toward a new treatment approach to cure leukemia
Halder Georg
KU Leuven
392.000 €
Foie
Traitements combinés
Attacking cholangiocarcinoma with driver-specific inhibitor combinations
Kerre Tessa
Universiteit Gent
592.000 €
Leucémie
Traitement ciblé
Drug response profiling of adult T-ALL to optimize salvage therapeutic strategies for refractory/relapsed patients
Lambrechts Diether & Lentacker Ine
KU Leuven & Universiteit Gent
720.000 €
Foie
Immunothérapie
Development and clinical validation of a personalized mRNA-based cancer vaccine for patients with advanced hepatocellular carcinoma
Laurent Sophie
Université de Mons
450.000 €
Tête et cou
Theranostique
Development of a novel theranostic boron-containing nanovector to enhance Boron Neutron Capture Therapy effectiveness in head and neck cancers
Leucci Eleonora
KU Leuven
660.000 €
Peau
Immunothérapie
An RNA-based strategy to overcome resistance to immune checkpoint blockade
Marine Jean-Christophe
KU Leuven
600.000 €
Peau
Immunothérapie
PreCision immUnotheRapy (CURe)
Moens Maarten
Vrije Universiteit Brussel
599.605 €
Intrathecal drug delivery systems versus comprehensive medical management for severe cancer pain: a randomized controlled trial
Offner Fritz
Universiteit Gent
289.724 €
Lymphome
Traitement ciblé
Finetuning a CD70 targeted nanoCAR Therapy for late stage Cutaneous T Cell Lymphoma
Smits Evelien
Universiteit Antwerpen
584.000 €
Cerveau
Traitement ciblé
An immunometabolic approach to pediatric and adult high-grade glioma: preclinical optimization of CAR-NK cell therapy with ketogenic diet
Thienpont Bernard
KU Leuven
527.000 €
Mélanome uvéal
DetectUM
Vandamme Timon
UZ Antwerpen
598.000 €
Neuroendocrine
1000 NEN genome
Vandekerckhove Bart
UZ Gent
600.000 €
Poumon
Immunothérapie
Safety and feasibility study of GALSOME-NEO, a personalized neoantigen targeted mRNA vaccine, in patients with locally advanced unresectable PD-L1 negative non-small cell lung cancer
Van den Eynde Marc & Raes Jeroen
UCLouvain & KU Leuven
598.000 €
Colorectal
Traitement ciblé
Investigating the role and the characteristics of tumor-resident bacteria in colorectal cancer (CRC) metastases
Van Gorp Toon
UZ Leuven
597.452 €
Ovaire
Homologous recombination deficiency (HRD) testing on liquid biopsies in ovarian cancer
Vermeesch Joris
UZ Leuven
493.900 €
Colorectal
Multi-omics cell-free DNA profiling as a non-invasive predictive and prognostic biomarker for colorectal cancer management
